Airborne biochemical attacks and building environment security (3): relationship between dose of CBW agents and human responses

In view of the emergencies such as chemical and biological terrorist attacks, proposes that the dose and dose-response relationship of chemical and biological weapon (CBW) agents should be taken as the basis of design and operation of the HVAC system. Presents the basic concept of dose, main routes of CBW agents invading people, and common parameters of dose. Presents the basic concept of dose-response relationship and relevant models of epidemiology and toxicology. Gives one general model and plots the dose-response curves of Bacillus anthracis and sarin based on it. Taking the attack scenarios for example, in which bacillus anthracis and sarin are continuously released into a room, calculates the variation of the concentration of agents in the air and the accumulate fatalities under six  operate conditions. Obtains preliminary rules and suggestions through analysis and discussion.